Holy Spirit Regional Catholic School opened in September 1960 under the leadership of Reverend John A. McGonegle, and was originally staffed by the Sisters of mercy. Through the years additions were made to the original four-classroom school building. A kindergarten was added in 1978. On November 15, 1989, a devastating tornado struck at 4:37 in the afternoon, destroying Holy Spirit Church and School. Holy Spirit Regional Catholic School was rebuilt and opened for the 1990-91 school year. Since that time there have been two more major additions to the school building.